Platycodin D Alleviates High-Glucose-Aggravated Inflammatory Responses in Oral Mucosal Cells by PI3K/mTOR Pathway

Oral mucosal diseases account for an increasing proportion of h?Man diseases. Among the many common risk factors that cause oral and systemic diseases, dietary factors, especially high sugar, are particularly prominent. Exhibiting therapeutic potential in treating certain inflammation-related platycodin D (PD) has been known to possess anti-inflammatory benefits cases cytokine-induced inflammation, a fact widely doc?Mented. However, there few studies about PD disease. Investigating effect on high-glucose (HG)-induced inflammatory responses cells was endeavor this study. The results revealed HG induced cell mortality, promoted activity factor (TNF-?, IL-1?, IL-6, IL-8), increased ROS production cells. Interestingly, obviously alleviated HG-induced response. Simultaneously, expressions PI3K mTOR were inhibited by PD. In addition, activation decreased protective To conclude, PI3K/mTOR signaling pathway found be inactivated, thereby restraining full immune inhibition pro-inflammatory cytokines, as indicating prevention inflammation response